It could only be expected that the coming of the settlers to America and their expansion in terms of population and land area would result in conflict with the Native Americans who lived there, called by the settlers "Indians". This term was incorrectly applied to the people of North America when Christopher Columbus first arrived at the Caribbean Islands, thinking he was in India. The term persisted, even after it was obvious that these people lived in the "new" continent of America.
The first settlers at Jamestown received a frosty welcome by the native peoples, who had already dealt with many explorations by the Europeans to their shores as well as fishing expeditions up and down along the east coast of America, primarily by French and English adventurers, in the decades prior to the first permanent settlement. By the time of the arrival of the Mayflower at Cape Cod, the natives of the area had experienced major devastation of their populations, due to the spread of diseases carried there by the Europeans from which the "Indians" had no natural immunity. Many Indians believed that the Europeans were somehow capable of purposely spreading plague. This was, as we shall see, only one of the grievances that led to bloody conflict in the nascent colonies.
The following wars took place in the Virginia and New England colonies between the colonists and the Native Americans:
(The Anglo-Powhatan Wars/Virginia)